BioGold CBD Gummies In noted biochemist Jeffrey Bland ‘s book, ” The 2-Day Rejuvenation Diet Program”. According to him that just one of the first symptoms of chronic poisoning is fatigue. Fatigue with low energy, muscle weakness, intestinal complaints and the inability to completely focus. Add to that, very much toxins on the inside body also bring headaches. Food additives, sugar, alcohol, constipation, caffeine withdrawal, hormonal imbalance, and exposure to known irritants like pollution, perfume and after-shaves can all cause headaches. Another sign in which you really need to have to detoxify.