Tadalafil (vidalista 20) is an active, reversible, selective inhibitor of phosphodiesterase type 5 (PDE 5) of particular cyclic guanosine monophosphate (cGMP). When sexual stimulation produces a local release of nitric oxide, restraint of PDE 5 happens, which leads to enhanced levels of cGMP in the corpus cavernosum of the penis.
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